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  • Home / Research Chemicals / buy BATRACHOTOXIN Phyllobates online
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Identification :
PRODUCT ID: L8301-BATRACHOTOXIN
CAS Number : 23509-16-2
T3DB ID: T3D2527
PubChem CID: 31958
EC Number: None
InChI Key: ISNYUQWBWALXEY-LKKHGHOQSA-N
RTECS Number: CR3990000
Product name BATRACHOTOXIN Physical form Film
CAS No. 23509-16-2 Melting point
RTECS CR3990000 Solubility In ethanol, methanol and DMSO
UNIPROT Optical Activity [alpha]D29 300 – 260° (c = 0.23 in methanol)
PubChem SID
PubChem CID 31958
Purity > 90 % (HPLC, TLC, Toxicity)
Toxicity(LD50) IPR-MUS LD50: 2 μg/kg
Chemical Name 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate)
Storage & Reconstitution
Recommandations Stable at room temperature, store preferably at 4°C
dissolve in ethanol or methanol
Savety Recommandations For research use only — not intended for food, diagnostic or therapeutic use
BATRACHOTOXIN from Phyllobates terribilis

Category: Research Chemicals
  • Description
  • Reviews (0)

Description

buy BATRACHOTOXIN Phyllobates online
Name BATRACHOTOXIN
Molecular formula C31H42N2O6
Description The strongest sodium channel activator so far
Alkaloid with a steroid skeleton, an oxazapine ring and a dimethylpyrrole carboxylate moiety , purified from skin extract of the poison dart frog Phyllobates terribilis
Biological activity BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.
BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpionalpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants.BATRACHOTOXIN from Phyllobates terribilis The strongest sodium channel activator so far. Batrachotoxin is an alkaloid purified from skin extract of the poison dart frog Phyllobates terribilis.
High chem is the world exclusive source of this toxin.
Molecular formula: C31H42N2O6
Chemical structure: Click on the picture on the left.
Molecular weight : 538.67 Da
Purity : > 90%
Biological Activity :
Batrachotoxin is a Na+ channels activator.
Batrachotoxin (BTX) is the most active alkaloid binding at receptor site-2 on sodium channels.
BTX activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation.

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BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.BTX binding induces many allosteric effects on other channel regions and increases the binding of scorpion alpha-toxins to receptor site-3, of brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Batrachotoxin-sensitive sodium channels are expressed in central and peripheral neurons and in both striated and cardiac muscle, where they regulate excitability.
BTX is used for the study of the function of sodium channels.
BTX is used for the study of the effects of other toxins and of different kinds of drugs (anesthetics, analgesics, antiarrhythmics, anticonvulsants, and antidepressants). Recommended doses: < 1 µg/kg.

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