buy BATRACHOTOXIN Phyllobates online

Description

buy BATRACHOTOXIN Phyllobates online
Name BATRACHOTOXIN
Molecular formula C31H42N2O6
Description The strongest sodium channel activator so far
Alkaloid with a steroid skeleton, an oxazapine ring and a dimethylpyrrole carboxylate moiety , purified from skin extract of the poison dart frog Phyllobates terribilis
Biological activity BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.
BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpionalpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants.BATRACHOTOXIN from Phyllobates terribilis The strongest sodium channel activator so far. Batrachotoxin is an alkaloid purified from skin extract of the poison dart frog Phyllobates terribilis.
High chem is the world exclusive source of this toxin.
Molecular formula: C31H42N2O6
Chemical structure: Click on the picture on the left.
Molecular weight : 538.67 Da
Purity : > 90%
Biological Activity :
Batrachotoxin is a Na+ channels activator.
Batrachotoxin (BTX) is the most active alkaloid binding at receptor site-2 on sodium channels.
BTX activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation.

buy BATRACHOTOXIN Phyllobates online

BTX also changes the selectivity of the channel to Na+ ions and makes it less selective, enabling larger ions to pass through the pore. EC50 (in vitro): 0.1 to 100 nanomolar.BTX binding induces many allosteric effects on other channel regions and increases the binding of scorpion alpha-toxins to receptor site-3, of brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.
Batrachotoxin-sensitive sodium channels are expressed in central and peripheral neurons and in both striated and cardiac muscle, where they regulate excitability.
BTX is used for the study of the function of sodium channels.
BTX is used for the study of the effects of other toxins and of different kinds of drugs (anesthetics, analgesics, antiarrhythmics, anticonvulsants, and antidepressants). Recommended doses: < 1 µg/kg.